# How EPA From Fish Oil May Calm Oxidative Stress Inside Liver Cells

*Dual miRNA-Mediated Axes Act in Concert in the Antioxidant Action of Eicosapentaenoic Acid: let-7c-3p/TFAM Drives Mitochondrial Biogenesis While miR-34c-5p/SIRT1 Potentiates Enzymatic Defenses.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Cell biochemistry and function
- **Sample Size**: Human liver cells (HepG2) in the lab
- **Authors**: Wang H, Lin Y, Li Y, Wu X, Lin J, Huang S, Li G
- **Published**: 2026-09-01
- **Topics**: Omega-3, Mitochondria, Oxidative Stress
- **DOI**: https://doi.org/10.1002/cbf.70298
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42708391/

## Summary

In human liver cells in a dish, the omega-3 fat EPA flipped two tiny genetic switches at once. One switch boosted the cells' ability to build new mitochondria (the energy factories), while the other ramped up the cells' own antioxidant enzymes. Together they lowered oxidative stress. This offers a possible explanation for why omega-3 keeps showing up in liver health research, though it's lab work, not people.

## Practical Takeaway

This early lab work hints at how EPA from fish oil may support cellular antioxidant defenses.

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