# NMN Plus Apigenin May Protect Aging Muscle and Bone Better Together

- **Evidence Level**: Preliminary
- **Journal**: Aging cell
- **Sample Size**: Aged mice (number not specified)
- **Published**: 2026-04-01
- **Topics**: NAD+, aging, musculoskeletal
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/41944220/

## Summary

In aged mice, combining the NAD booster NMN with apigenin (a compound found in parsley and chamomile) reduced cartilage breakdown, bone loss, and muscle wasting. The combo works by both producing more NAD+ and blocking enzymes that consume it. Treated mice also showed better exercise capacity. The benefits appeared to work through SIRT3 activation and changes in gut bacteria that produce a helpful fat molecule.

## Practical Takeaway

This study suggests combining NAD boosters with apigenin may better preserve musculoskeletal health in aging.

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