Exercise Linked to Younger Biological Age, But Effect Is Modest
Based on: Physical activity and biological age measured by DNA methylation clocks: a systematic review and meta-analysis.
Pulling together 44 studies on nearly 145,000 people, researchers found that more physical activity is tied to a younger biological age, but only on certain epigenetic clocks. The effect showed up clearly on GrimAge and Horvath clocks, but not on Hannum or PhenoAge. The size of the benefit was small, and most data came from snapshot studies, so we can't say exercise actually causes the slowdown yet.
Key Insight
This study suggests staying physically active may be associated with a slightly younger biological age on certain epigenetic clocks.
Original Paper
Shan J, Tay JH, Wang W, Tan R, Joshi R, Maier AB, Feng L
Conflict of Interest Disclosure: One author co-founded a longevity medicine clinic and sits on biomarker and longevity boards. Other authors report no conflicts.
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Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.