TA-65

TA-65 is a proprietary, purified cycloastragenol-enriched extract from Astragalus membranaceus, marketed by T.A. Sciences (licensed by Geron) and sold as a telomerase-activating dietary supplement. Human data are sparse: Salvador et al. (Rejuvenation Research, 2016) reported a 1-year randomized double-blind placebo-controlled trial in 117 CMV-positive adults with modest effects on telomere length, and a subsequent 500-subject Geriatrics trial reported a small reduction in senescent CD8+CD28− T-cells. No rigorous RCT shows benefit on hard healthspan endpoints (frailty, mortality, dementia, cardiovascular events). In 2018 the FTC issued a complaint and final consent order against marketing claims; TA-65 is regulated in the US as a dietary supplement under DSHEA, not as an approved drug, and the EU treats astragalus extracts as food supplements.