28 studies
Research Library
Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.
Longevity Protein Klotho May Protect Against Cognitive Decline in Parkinson's
People with Parkinson's disease who carry a specific variant of the klotho gene tended to perform better on executive thinking tasks across two separate groups. In mice engineered to model Parkinson's, boosting klotho levels improved brain function and reduced alpha-synuclein (a toxic protein that builds up in Parkinson's). The cognitive benefits showed up without improving motor symptoms. Lab experiments suggested klotho may work by helping brain cells clear that toxic protein more effectively.
Two Opposing Brain Fuel Patterns May Predict Who Keeps Their Cognition With Age
Brain white matter (the wiring that connects brain regions) uses glucose differently depending on where you look. In over 3,000 participants across two studies, higher glucose use in expected areas like the corpus callosum linked to better thinking skills. But higher glucose use in unusual areas like the corona radiata linked to worse cognition, likely a sign the brain is compensating. Over time, people with strong "normal" metabolism and low "compensatory" metabolism declined more slowly.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
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