GHK-Cu (Copper Tripeptide-1)

GHK-Cu is the tripeptide glycyl-L-histidyl-L-lysine, bound to copper(II). It is a fragment of a larger blood protein (α2-macroglobulin), whose level in your plasma drops with age. In topical cosmetic skincare, it has been marketed for decades for wound healing, skin remodeling, and hair growth. But the supporting human trials are small, and the broader literature is mostly mechanistic and in lab dishes (it modulates more than 4,000 genes, with effects on fibroblasts and blood-vessel growth). Topical cosmetic products are widely sold in the EU and US under cosmetic rules. But no GHK-Cu drug product is approved by the FDA or EMA. Injectable GHK-Cu was placed on the FDA's 503A Category 2 list in 2023. It was removed from Category 2 on 22 April 2026, alongside eleven other peptides whose nominators withdrew. A PCAC consultation is scheduled for before the end of February 2027.

Last reviewed: June 22, 2026

This definition is educational and is not medical advice, a diagnosis, or treatment. Talk to a doctor about any health decisions. Read our full medical disclaimer