93 studies
Research Library
Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.
May 10–16, 2026
2Blood NAD+ Levels Stay Flat With Age, Challenging Popular Aging Theory
One of the most repeated ideas in longevity is that NAD+ declines as we age, a story that helped make NR and NMN household names in the space. This large, carefully controlled study takes a closer look. Across seven independent cohorts and more than 300 people, researchers found that whole-blood NAD+ levels stayed remarkably stable with age, and didn't shift meaningfully in response to exercise, protein-rich diets, or multimodal lifestyle interventions in older adults. Importantly, NR supplementation did raise blood NAD+ as expected, confirming that the supplements work pharmacologically, the question is just whether blood NAD+ is the right thing to be measuring in the first place.
Combining Wearables With Blood Proteins Sharpens Biological Age Tests
Researchers built a new biological age model that combines blood protein data with wearable device readings. It predicted mortality risk better than either tool alone and cut prediction error by 21%. The model also flagged common drugs like GLP-1 agonists and ACE inhibitors as linked to a younger biological age in specific organ systems.
May 3–9, 2026
2New Aging Clocks Reveal Blood Clotting Factors May Drive Organ Decline
Researchers built a multi-layered aging clock using clinical, physiological, and molecular data from over 2,000 Chinese adults. They found that plasma proteins can predict both your age and how well your body is holding up. The standout discovery: clotting factors pile up with age and may fuel organ-wide aging and inflammation.
Why Standard Protein Advice May Fall Short for Older Adults
This review argues that general protein guidelines may not be enough for older adults trying to keep their muscle. Older bodies need more protein, spread evenly through the day, with a focus on leucine-rich foods like animal proteins. The authors note that creatine, vitamin D, collagen, and omega-3s, combined with resistance training, may further support muscle health.
Apr 12–18, 2026
3Your Blood Is Both a Mirror and a Driver of How Fast You Age
Scientists are finding that the stuff floating in your blood, proteins, metabolites, and tiny vesicles, doesn't just reflect your age. It actively sets the pace of aging across organs. In animal studies, swapping old blood for young blood or filtering out pro-aging factors restored tissue function and even extended lifespan. Human trials using plasma exchange are now showing early promise for age-related decline.
Cholesterol, Immune Cells, and IGF-1 Emerge as Key Longevity Signals
Researchers combed through massive genetic databases to find what actually drives long life and slower biological aging. Three factors stood out: cholesterol levels, immune cell traits, and IGF-1 (a growth hormone linked to aging). They also flagged 30 genes and several proteins as possible drug targets for future anti-aging therapies.
How Lactate From Exercise May Rewrite Your Genes to Slow Aging
When you work out hard, your muscles pump out lactate, the same stuff people used to blame for soreness. Researchers now think lactate acts as a messenger that tags proteins through a process called lactylation, linking your workout to long-term changes in how genes behave. This may explain how exercise protects mitochondria, calms inflammation, and keeps stem cells working across the brain, heart, and muscles. It's still early, and much of the evidence comes from animal and cell studies.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
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