Cellular reprogramming

Cellular reprogramming is the experimental conversion of one cell type into another, most often a differentiated somatic cell into a pluripotent stem cell, by forcing expression of specific transcription factors such as OSKM. The process resets the epigenome, including DNA methylation and histone marks, effectively reversing many molecular age signatures. It underpins iPSC technology and is being explored as a route to organ regeneration and systemic rejuvenation.