mTOR

mTOR (mechanistic target of rapamycin) is a serine/threonine kinase that integrates signals from amino acids, growth factors, and cellular energy status to regulate protein synthesis, cell growth, and autophagy. It functions in two complexes, mTORC1 and mTORC2. Chronic mTORC1 hyperactivation accelerates aging phenotypes, while pharmacologic inhibition with rapamycin extends lifespan in multiple model organisms, making mTOR one of the most validated longevity targets.