Retinol Cream: Stronger Dose Brought More Redness, Same Barrier
Graded Preliminary — chance assigned 28 women to two retinol strengths for twelve weeks; there was no retinol-free group, and the subgroups had only five women each.
- Design
- Randomized controlled trial
- Participants
- 38
- Duration
- 12 weeks
- Funding
- —
A cream with 0.247 percent retinol did not improve the skin barrier more than one with 0.104 percent, but it caused redness more often.
Retinol is a form of vitamin A found in many anti-aging creams. In a small study, a stronger cream gave the skin's protective layer no extra benefit. After twelve weeks, skin in both groups was more hydrated and lost less water. The stronger cream felt smoother to users but caused redness more often.
The study involved 38 women aged 40 to 61. Of these, 28 were chosen at random to use a cream with 0.104 or 0.247 percent retinol. Wrinkles became slightly shallower in both groups, but the change was not clear. Skin elasticity showed no measurable change either. In five women, ultrasound after eight weeks showed a slightly thicker outer skin layer than on the face half treated with a retinol-free cream.
The main part of the study had no group without retinol. So it is not certain that the improvements came from retinol itself. The subgroups were very small. The retinol creams also contained other ingredients such as sea buckthorn oil. The authors see the weaker cream as a good starting option.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
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