Skip to content
Journal ArticleACS omega·Aug 2026

Vitamin K2 Cream Smoothed Wrinkles in an 8-Week Split-Face Test

Key Insight

This study suggests topical MK-7 may modestly improve skin firmness, though the trial was small and short.


Vitamin K2 (MK-7) is usually talked about for bones and arteries, but here it was rubbed on the skin. Women aged 35 to 60 used a 0.05% MK-7 cream on one side of their face and neck and a placebo on the other for eight weeks. The K2 side showed less wrinkle roughness, better elasticity, and less sagging. In lab-grown skin cells, MK-7 also boosted energy production and raised the NAD+/NADH ratio.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.