Why Alzheimer's May Look Like a Viral Infection That Isn't There
Graded Preliminary — narrative review proposing a mechanistic hypothesis, drawing on cell and animal work with no new human data tested.
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- Authors declare no competing interests.
This review proposes that Alzheimer's behaves like the brain fighting a fake viral infection. Old retrotransposons and leaked mitochondrial DNA trick immune cells into thinking there's a virus, triggering chronic inflammation and turning brain support cells into zombie-like senescent cells. The authors suggest that HIV drugs (NRTIs) and senolytics could one day target this hidden cascade. It's a fresh angle after years of failed amyloid-focused drugs.
Conflict of Interest Disclosure: Authors declare no competing interests.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.