Cycloastragenol

Cycloastragenol is the aglycone of astragaloside IV, a cycloartane-type triterpenoid hydrolysis product from Astragalus membranaceus root. In cellular assays it produces mild, transient activation of telomerase reverse transcriptase (TERT) and has been reported to improve cardiac, neurological, and metabolic readouts in rodent models. Human data are limited to small studies of the proprietary TA-65 preparation; no independent rigorous RCT exists for free-form cycloastragenol on aging endpoints. Subchronic toxicity and genotoxicity studies support food-supplement use, and cycloastragenol is sold in the US under DSHEA and in the EU as a food supplement, but it has no approved drug indication in any jurisdiction as of 2026.