NMN Plus Apigenin May Protect Aging Muscle and Bone Better Together
In aged mice, combining the NAD booster NMN with apigenin (a compound found in parsley and chamomile) reduced cartilage breakdown, bone loss, and muscle wasting. The combo works by both producing more NAD+ and blocking enzymes that consume it. Treated mice also showed better exercise capacity. The benefits appeared to work through SIRT3 activation and changes in gut bacteria that produce a helpful fat molecule.
Key Insight
This study suggests combining NAD boosters with apigenin may better preserve musculoskeletal health in aging.
Related Studies
Most Older and Darker-Skinned Adults in Northern Britain Are Low on Vitamin D, Even in Summer
Researchers screened older adults and people with darker skin tones in northern Britain for vitamin D levels across the year. More than half of older adults and over 70% of ethnic minority adults had insufficient or deficient vitamin D. Summer sunshine did not fix the problem. Sun exposure alone seems to fall short for these groups at higher latitudes.
Blood NAD+ Levels Stay Flat With Age, Challenging Popular Aging Theory
One of the most repeated ideas in longevity is that NAD+ declines as we age, a story that helped make NR and NMN household names in the space. This large, carefully controlled study takes a closer look. Across seven independent cohorts and more than 300 people, researchers found that whole-blood NAD+ levels stayed remarkably stable with age, and didn't shift meaningfully in response to exercise, protein-rich diets, or multimodal lifestyle interventions in older adults. Importantly, NR supplementation did raise blood NAD+ as expected, confirming that the supplements work pharmacologically, the question is just whether blood NAD+ is the right thing to be measuring in the first place.
Eating More Fruits, Fish, Nuts, and Dairy Tied to Slower Cognitive Decline
In over 3,000 Chinese older adults tracked for about five years, those who ate more from six protective food groups (fruits, vegetables, nuts, legumes, fish, and dairy) showed slower cognitive decline. People scoring highest on this diet scale declined about 0.42 points per year slower on a cognitive test compared to those scoring lowest. The effect was modest but consistent across different ways of measuring cognition.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.