Eight Hyped Compounds Failed to Extend Lifespan in a Major Mouse Study
This study suggests that dose and timing matter enormously, and early lifespan results in mice often don't hold up.
The NIA's Interventions Testing Program tested eight compounds across three lab sites in genetically diverse mice. None extended lifespan. That includes astaxanthin, alpha-ketoglutarate, pioglitazone, atorvastatin-telmisartan, and others with prior promising results. Some compounds previously shown to work at different doses or start ages didn't replicate under new conditions. Two drugs actually shortened lifespan in female mice.
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Quail Bred to Reproduce More Aged Faster, Supporting a Core Theory of Aging
Researchers selectively bred Japanese quail for higher or lower reproductive effort across several generations.
We May Not Be Aging Slower. We're Just Starting Later.
A big question in longevity research is whether rising life expectancy means we're actually aging more slowly.