51 studies
Research Library
Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.
What Centenarians' Immune Systems Reveal About Escaping Age-Related Disease
People who live past 100 tend to have immune systems that look surprisingly young. This review found they have less chronic inflammation, better cellular cleanup (autophagy), and gut bacteria patterns linked to healthy aging. Those living past 110 often have immune profiles resembling much younger adults.
Centenarians Show a Distinct Metabolic Profile Tied to Bile Acids and NAD+
People who live past 100 have a unique metabolic fingerprint. In a study of 213 participants from the New England Centenarian Study, extremely long-lived individuals had higher levels of certain bile acids and lower levels of bilirubin compared to younger controls. Higher bile acid and steroid levels were linked to lower mortality risk. The researchers also built a "metabolomic clock" that estimates biological age, and deviations from it predicted death risk.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
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